André is a Paediatrician and Paediatric Pulmonologist with a special interest in clinical immunology. He previously served as Chairperson of the Allergy Society of South Africa (ALLSA) and currently leads the ALLSA Primary Immune Deficiency Diseases Interest Group (PIDDSA). He helped to establish the Allergy and Clinical Immunology Foundation of South Africa (AFSA) as one of its founding members. André spent most of his career in private practice but remained closely involved in academic medicine.

He assisted in setting up the clinical service for primary immunodeficiency diseases at the University of Pretoria and was awarded an extraordinary professorship. He has since returned to full-time academic work and now holds the University of Pretoria–Ampath Chair for Inborn Errors of Immunity and Allergology.

He also serves on the boards of the African Society for Immunodeficiencies (ASID) and the South African Immunology Society (SAIS) and is the co-director of the University of Pretoria FOCIS Centre of Excellence for Clinical Immunology.